Optometry Research Today is a free monthly online journal that collates and summarizes the latest research about Optometry, including details on myopia, optometric practice, therapy. | ||||||||
|
Recovery from axial myopia induced by a monocularly deprived facemask in adolescent (7-week-old) guinea pigs.Zhou X, Lu F, Xie R, Jiang L, Wen J, Li Y, Shi J, He T, Qu J School of Optometry and Ophthalmology, Eye Hospital, Wenzhou Medical College, 270 Xueyuan Road, Wenzhou, Zhejiang 325003, China; Key Laboratory of Vision Science, Ministry of Health PR China, 270 Xueyuan Road, Wenzhou, Zhejiang 325003, China. PURPOSE: Guinea pigs have been increasingly used as an animal model for experimental myopia. Infant guinea pigs are susceptible to recovery from myopia within 2weeks of form deprivation. This study investigated whether adolescent guinea pigs are susceptible to recovery from myopia after a longer period of form deprivation. METHOD: Twenty-two guinea pigs (age of 3weeks) were randomly assigned to two groups: MDF (monocularly deprived facemask, n=11) and normal control (free of form deprivation, n=11). All animals underwent biometric measurement (refraction, corneal curvature and axial length) prior to the experiment. Animals in the MDF group wore a facemask that covered the right eye for 4weeks. The MDF was then removed and biometric measurement was performed immediately and at 2, 6, 10 and 14days. The same measurement was performed in the normal control group at time-points matching those of the MDF group. RESULTS: The MDF eyes were approximately 4D more myopic with a greater increase in vitreous length by 0.12mm compared to either the fellow or the normal control eyes after form deprivation (p<0.01). This relative myopia shifted rapidly towards hyperopia within 2days after removal of the MDF, followed by a more gradual recovery. A complete recovery occurred by 6days after removal of the MDF compared to the fellow and normal control eyes (p>0.05). Vitreous length in the MDF eyes slightly reduced within 2days after removal of the MDF and then remained steady. The MDF eyes were similar to both the fellow and normal control eyes in vitreous length (p>0.05) 6days after removal of the MDF. There was no significant difference between the MDF, fellow and normal control eyes in the other axial components during the form deprivation and recovery period. CONCLUSION: Adolescent guinea pigs are susceptible to recovery from MDF-induced myopia. The refractive recovery is mainly correlated to the inhibited axial elongation of the vitreous chamber of the previously deprived eyes. Published 26 March 2007 in Vision Res, 47(8): 1103-11.
© 2005-2008 Optometry Research Today. All Rights Reserved. |
| ||||||
