Optometry Research Today is a free monthly online journal that collates and summarizes the latest research about Optometry, including details on myopia, optometric practice, therapy.

Retinal pigment epithelium tears following intravitreal ranibizumab therapy.

Kiss C, Michels S, Prager F, Geitzenauer W, Schmidt-Erfurth U

Department of Ophthalmology and Optometry, Medical University of Vienna, Vienna, Austria.

Two patients with choroidal neovascularization secondary to age-related macular degeneration (AMD) developed a retinal pigment epithelial (RPE) tear following intravitreal injection of ranibizumab. One patient developed the RPE tear within 2 weeks of the injection, the other within 6 weeks of a second injection. Both patients presented with vision loss of one line at diagnosis of the RPE tear. During long-term follow-up, visual acuity improved in one patient by one line and deteriorated in the second patient by three lines. RPE tears may occur after intravitreal injection of ranibizumab in patients with neovascular AMD, probably because of the rapid regression of the fibrovascular membrane.

Published 21 November 2007 in Acta Ophthalmol Scand, 85(8): 902-3.
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